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Item
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value
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Product name
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B7-33 |
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Function
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B7-33 is a single-chain peptide. It is derived from a naturally occurring compound called H2-Relaxin. Relaxin proteins are a family of four proteins comprising Relaxin, Insulin-like peptide 3, H3-relaxin, and insulin-like peptide All these agonists can express antioxidant, anti-inflammatory, and wound healing properties. However, Relaxin, in addition to possessing above mentioned properties, also exhibits antihypertrophic, vasodilator, and angiogenic properties. |
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Package
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10 mg / vial,10 vials /box or customized for you
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Storage
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keep them in cool place
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B7-33 is a single-chain peptide. It is derived from a naturally occurring compound called H2-Relaxin. Relaxin proteins are a family of four proteins comprising Relaxin, Insulin-like peptide 3, H3-relaxin, and insulin-like peptide 5. They all possess pleiotropic actions impacting the cardiovascular system, musculoskeletal system, reproduction system, etc. These proteins perform these actions through four types of receptors, namely (RXFP1/2 and RXFP3/4). Various ligands, such as cAMP and corticotropin-releasing hormone, stimulate these receptors.
All these agonists can express antioxidant, anti-inflammatory, and wound healing properties. However, Relaxin, in addition to possessing above mentioned properties, also exhibits antihypertrophic, vasodilator, and angiogenic properties. This is why Relaxin and its derivatives have been of great interest for researchers to explore its further benefits.
B7-33 Function
B7-33 preferentially stimulates the pERK pathway over the cAMP pathway. The pERK pathway regulates cell cycle arrest in the G1 phase and has been implicated in several diseases like Alzheimer's and Crutzfeld-Jacob.
By blocking cell cycle progression in cells with RXFP1 receptors, B7-33 exercises its anti-fibrotic effects through the ability to stimulate RXFP1-angiotensin II type 2 receptor heterodimering, which activates pERK1/2 signaling and, thus triggers the increased production of the collagen-degrading enzyme matrix metalloproteinase (MMP) -2.
B7-33 Benefits
B7-33 is a revolutionary anti-inflammatory, antioxidant, and wound healing agent. It's also a vasodilator and a blood vessel growth stimulator. Additionally, this product has very potent anti-fibrotic effects, so it can be used to treat acute heart failure and other fibrotic disorders. It treats Alzheimer Disease (AD) and Creutzfeldt-Jakob Disease (CJD).
B7-33 is much better than its "parent peptide" named H2-Relaxin because B7-33 doesn't activate cAMP pathway. By non-activating cAMP, B7-33 avoids basically all of the undesired effects normally found in H2-Relaxin, but still keeps all of H2-Relaxin's positive effects to the user's organism. B7-33 reduces the long-term scarring following heart damage, and it's the first treatment approved for acute heart failure in the last 20 years.
It protects against heart failure, therefore improving heart function and avoiding long-term symptoms and complications. It also reduces in approximately 50% the post-injury heart scarring. It benefits people with asthma, lung fibrosis and lung inflammation, as well as people with kidney conditions. Much differently from H2-Relaxin, B7-33 does not promote any kind of tumor growth, even when administered in higher doses (that's why B7-33 is absolutely safe).
This product offers great protection against endothelial dysfunction and treats long-term scarring in general. Its mechanism of action causes vasorelaxation that is useful to treat certain cardiovascular conditions as well as preeclampsia of pregnancy, even in severe cases. And, when it comes to pregnancy, B7-33 improves blood supply between mother and child (fetus), which makes it safer for women to carry their children to term in a manner that is secure for both. This product helps the body to accept implants and foreign objects in general, preventing the organism from naturally rejecting them. This acceptance by the body is very welcome in cases of medical device implantations, for instance. Lastly, B7-33 reduces blood pressure and protects vasculature.
FAQ
Q1: How to confirm the Product Quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirement for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high-value product, our MOQ starts from 1g and generally starts from 10g.
For other low-value products, our MOQ starts from 100g and 1kg.
Q4: How to place an order and make payment?
A: You can send us your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Company profile
Wuhan Taijikang Technology Co., Ltd. mainly engaged in polypeptide products, synthetic polypeptide amino acids, beauty slimming products, pharmaceutical raw materials and fine chemical products. Has a strong R & D ability, exquisite synthesis technology, advanced quality control means. Effectively promote joint venture cooperation with major enterprises and manufacturers, and serve the society and users with the concept of industrial development. We always adhere to the market demand-oriented, and continue to synthesize new high-tech chemical products and pharmaceutical intermediates, mainly exported to the United States, Europe, South Africa, Nigeria and other countries and regions, there is a great price advantage. We provide samples to test the quality as a trial order, because I have confidence in the quality of our products. Many foreign customers will speak highly of our goods when they receive them. Our products, excellent quality, customs clearance rate 100%, firmly ensure that your goods to your hands door to door.
High quality and competitive price.
1. We can provide samples for testing.
2. All purity >99%.
As a manufacturer, we can supply high quality products at ex-factory prices.
Fast and safe delivery.
1. The package can be delivered within 3-5 working days after receiving the payment tracking number.
2. Safe and prudent mode of transportation for your choice.
3. Customs qualification rate >99%.
4. We have established long-term and stable cooperative relations with DHL, FedEx, TNT, UPS and HK EMS. If the parcel is lost, we will replace it free of charge.
Our customers are all over the world.
1. Professional services and rich experience make customers feel at ease, sufficient inventory and fast delivery to meet their needs.
2. Feedback from the market and goods will be appreciated. It is our responsibility to meet customer requirements.
3. High quality, competitive price, fast delivery, first-class service has won the trust and praise of customers.
The price can be reduced pls don't hesitate to contact us!
Our advantage
1. Parcel can be sent out in 24 hours after payment tracking number available.
2. Secure and discreet shipment verious transportation methods for your choice.
3. Customs pass rate >99%.
4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
5.Sample order are welcome.
How to make an order :
1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .
FAQ
Q1: How to confirm the Product Quality before placing orders?
A: By sending you available samples.Or if you have special requirements on the goods, we can prepare samples according to your requirement for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customer. In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
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